what I've been reading
New mitochondria and VDAC1 research, summarised in plain language and always linked to the source. Below the highlights, filter the whole archive by topic, category, year or tag.
A De Montfort University team knocked out three separate mitochondrial quality-control genes in mouse cells and found that losing HtrA2 or the mitophagy regulator PINK1 made cells noticeably more prone to senescence after DNA-damaging drugs, while the DNA damage response itself didn't fully explain which cells actually became senescent.
read the write-up →→ Simons-Weston et al., Cellular Signalling 2026 · doi.org/10.1016/j.cellsig.2026.112763
A Southwest Medical University team traced hyperglycemia-driven damage in retinal Muller cells to a calcium channel, TRPM7, that pushes VDAC1 expression up and forces open the mitochondrial permeability pore, and silencing TRPM7 protected the cells.
read the write-up →→ Guo et al., Cellular Signalling 2026 · doi.org/10.1016/j.cellsig.2026.112728
A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells, and calmed the whole thing down with the oligomerization blocker VBIT-12.
the full story →→ Ren et al., Cell Signalling 2026 · doi.org/10.1016/j.cellsig.2026.112642
Every post and news piece, split by domain (VDAC1 vs mitochondria), category, year and tag.