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news · 4 Aug 2026
Losing the mitochondrial quality-control genes HtrA2 or PINK1 makes cells more likely to turn senescent after DNA damage
A De Montfort University team knocked out three separate mitochondrial quality-control genes in mouse cells and found that losing HtrA2 or the mitophagy regulator PINK1 made cells noticeably more prone to senescence after DNA-damaging drugs, while the DNA damage response itself didn't fully explain which cells actually became senescent.
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explainer · 12 Jul 2026
So what actually is VDAC1, and why do I care this much?
The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it, with a spin-it-yourself 3D structure.
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news · 8 Jul 2026
Mendelian randomization flags specific mitochondrial genes as likely causal in acute and chronic kidney disease
A Sichuan group cross-referenced the whole MitoCarta gene inventory against genetics of acute and chronic kidney disease and pulled out a handful of mitochondrial genes that look causal.
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personal · 3 Jul 2026
Why a PSEN1 carrier ended up obsessed with mitochondria
The origin story of this blog, a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for.
