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news · 1 Aug 2026
In diabetic retinopathy, a calcium channel called TRPM7 drives VDAC1 up and forces open the mitochondrial pore in retinal cells
A Southwest Medical University team traced hyperglycemia-driven damage in retinal Muller cells to a calcium channel, TRPM7, that pushes VDAC1 expression up and forces open the mitochondrial permeability pore, and silencing TRPM7 protected the cells.
