#mtDNA

• news · 22 Jul 2026 In septic T cells, VDAC1 oligomers open a pore that leaks mtDNA and drives inflammation — and VBIT-12 shuts it down
  A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells — and calmed the whole thing down with the oligomerization blocker VBIT-12.
• news · 10 Jul 2026 A mitochondria-targeting nanozyme restarts mitophagy in cartilage and switches off mtDNA-driven inflammation in osteoarthritis
  Bioengineers at Shanghai Ninth People's Hospital built a mitochondria-targeting nanozyme that mops up damage in cartilage cells, restarts mitophagy, and shuts down the mtDNA→cGAS/STING inflammation loop in osteoarthritis.
• drug-watch · 8 Jul 2026 VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
  A running summary of the VBIT compounds that block VDAC1 oligomerization — where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.

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