VDAC1: the gene, the sequence, where it's switched on

01The gene, in numbers

02Where it's activated

VDAC1 is a housekeeping gene expressed in essentially every tissue — but it is dialled up highest in the most energy-hungry ones (skeletal muscle, heart, brain), which is exactly why those tissues are so exposed when VDAC1 misbehaves. Bars = median RNA expression (TPM), GTEx v8.

03The protein sequence

Human VDAC1, 283 residues (UniProt P21796). The first ~25 form the N-terminal helix that sits inside the pore.

04Sources

Fetched 2026-07-27 from public databases — go live for the latest:

• GTEx v8 — median gene expression (TPM) across 54 tissues
• UniProt P21796 — canonical protein sequence (283 aa)
• Ensembl ENSG00000213585
• NCBI Gene 7416