The resource shelf

Varda Shoshan-Barmatz wrote the canonical review series on VDAC1 as a hub for metabolism, calcium and cell death. Any of them is a great foundation.

The mechanistic heart of the disease story: how VDAC1 grouping up forms a big pore that leaks mitochondrial contents.

Where my head lives, VDAC1's links to amyloid, tau and mitochondrial dysfunction in the brain.

If you read a single VDAC1 paper, read this one. Kim, Shoshan-Barmatz and colleagues showed VDAC1 oligomers form the outer-membrane pore that releases mtDNA fragments and drives the interferon response, and that VBIT-4 blocks it and eases lupus in mice. It's the anchor of my whole VBIT reading list. (Science 366:1531–1536; PMID 31857488.)

Follow-on work testing VDAC1-oligomerization inhibitors in metabolic, kidney, heart and brain models. See how far the idea reaches.

The immune side: why mitochondrial DNA in the wrong place acts like a danger signal. Context for why a leaky pore matters.

The reference sheet: sequence, structure, function, interactions.

The crystal structure my 3D viewer loads. Download it, open it in any viewer, poke around.

Predicted 3D structure of the β-barrel. Fun to spin while thinking about the pore.

Where VDAC1 is expressed across tissues and cancers, with the imaging to prove it.

A one-stop aggregator that links out to just about everything else.

MitoCarta is the reference inventory of mitochondrial proteins. The Mootha lab's work is a masterclass in mito biology.

A community encyclopedia of mitochondrial physiology and bioenergetics. Great for definitions done right.

The human mitochondrial genome database, mtDNA mutations, variants and disease links.

How cells clear damaged mitochondria before they cause trouble. The upstream story to a lot of what happens at VDAC1.

A community genomics portal built specifically for mitochondrial disease, variants, phenotypes and tools in one place.

The reference list of ~1,140 genes with strong evidence of mitochondrial localization, with sub-organelle and pathway annotations.

Gene expression across tissues, cell types and conditions, a second opinion to GTEx for 'where is this switched on?'

The exact source behind my /gene/ page's expression chart. Go here for the full, live tissue breakdown.

Beautifully drawn, curated pathway maps. Great for seeing where VDAC1 and mitophagy sit in the bigger network.

The clinical/research society, guidelines, meetings and the people who treat mitochondrial disease.

Patient- and family-facing: mitochondrial-health resources, support and research funding. The human side of the field.

My homepage, basically. Sorted newest-first.

The wider beat, beyond VDAC1.

The not-yet-peer-reviewed edge. Grain of salt included.