The resource shelf

Varda Shoshan-Barmatz wrote the canonical review series on VDAC1 as a hub for metabolism, calcium and cell death. Any of them is a great foundation.

The mechanistic heart of the disease story: how VDAC1 grouping up forms a big pore that leaks mitochondrial contents.

Where my head lives — VDAC1's links to amyloid, tau and mitochondrial dysfunction in the brain.

If you read a single VDAC1 paper, read this one. Kim, Shoshan-Barmatz and colleagues showed VDAC1 oligomers form the outer-membrane pore that releases mtDNA fragments and drives the interferon response — and that VBIT-4 blocks it and eases lupus in mice. It's the anchor of my whole VBIT reading list. (Science 366:1531–1536; PMID 31857488.)

Follow-on work testing VDAC1-oligomerization inhibitors in metabolic, kidney, heart and brain models. See how far the idea reaches.

The immune side: why mitochondrial DNA in the wrong place acts like a danger signal. Context for why a leaky pore matters.

The reference sheet: sequence, structure, function, interactions.

The crystal structure my 3D viewer loads. Download it, open it in any viewer, poke around.

Predicted 3D structure of the β-barrel. Fun to spin while thinking about the pore.

Where VDAC1 is expressed across tissues and cancers, with the imaging to prove it.

A one-stop aggregator that links out to just about everything else.

MitoCarta is the reference inventory of mitochondrial proteins. The Mootha lab's work is a masterclass in mito biology.

A community encyclopedia of mitochondrial physiology and bioenergetics. Great for definitions done right.

The human mitochondrial genome database — mtDNA mutations, variants and disease links.

How cells clear damaged mitochondria before they cause trouble. The upstream story to a lot of what happens at VDAC1.

A community genomics portal built specifically for mitochondrial disease — variants, phenotypes and tools in one place.

The reference list of ~1,140 genes with strong evidence of mitochondrial localization, with sub-organelle and pathway annotations.

Gene expression across tissues, cell types and conditions — a second opinion to GTEx for 'where is this switched on?'

The exact source behind my /gene/ page's expression chart. Go here for the full, live tissue breakdown.

Beautifully drawn, curated pathway maps. Great for seeing where VDAC1 and mitophagy sit in the bigger network.

The clinical/research society — guidelines, meetings and the people who treat mitochondrial disease.

Patient- and family-facing: mitochondrial-health resources, support and research funding. The human side of the field.

My homepage, basically. Sorted newest-first.

The wider beat, beyond VDAC1.

The not-yet-peer-reviewed edge. Grain of salt included.