-
news · 22 Jul 2026
In septic T cells, VDAC1 oligomers open a pore that leaks mtDNA and drives inflammation, and VBIT-12 shuts it down
A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells, and calmed the whole thing down with the oligomerization blocker VBIT-12.
-
explainer · 12 Jul 2026
So what actually is VDAC1, and why do I care this much?
The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it, with a spin-it-yourself 3D structure.
-
drug-watch · 8 Jul 2026
VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
A running summary of the VBIT compounds that block VDAC1 oligomerization, where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.
-
news · 24 Jun 2026
x-tosis lands a $2.74M Michael J. Fox Foundation grant to push XTS001, a brain-penetrant VDAC1-oligomerization blocker, toward Parkinson's
x-tosis has been awarded a $2.74M grant from The Michael J. Fox Foundation to advance XTS001, an oral, brain-penetrant molecule that blocks VDAC1 oligomerization, toward Parkinson's development.
