Review: forcing ER-to-mitochondria calcium overload through the IP3R–GRP75–VDAC1 relay as a way to kill cancer cells

A team at Yantai University just put out a big-picture review on calcium overload as a cancer-killing strategy — how the ER and mitochondria pass calcium back and forth across their contact sites, with VDAC1 sitting right in the middle of the IP3R–GRP75–VDAC1–MCU relay. If you want the wider map of how VDAC1 fits into calcium and cell death (rather than one narrow experiment), start here.