#VDAC1

• news · 1 Aug 2026 In diabetic retinopathy, a calcium channel called TRPM7 drives VDAC1 up and forces open the mitochondrial pore in retinal cells
  A Southwest Medical University team traced hyperglycemia-driven damage in retinal Muller cells to a calcium channel, TRPM7, that pushes VDAC1 expression up and forces open the mitochondrial permeability pore, and silencing TRPM7 protected the cells.
• news · 22 Jul 2026 In septic T cells, VDAC1 oligomers open a pore that leaks mtDNA and drives inflammation, and VBIT-12 shuts it down
  A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells, and calmed the whole thing down with the oligomerization blocker VBIT-12.
• explainer · 12 Jul 2026 So what actually is VDAC1, and why do I care this much?
  The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it, with a spin-it-yourself 3D structure.
• drug-watch · 8 Jul 2026 VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
  A running summary of the VBIT compounds that block VDAC1 oligomerization, where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.
• personal · 3 Jul 2026 Why a PSEN1 carrier ended up obsessed with mitochondria
  The origin story of this blog, a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for.
• news · 24 Jun 2026 x-tosis lands a $2.74M Michael J. Fox Foundation grant to push XTS001, a brain-penetrant VDAC1-oligomerization blocker, toward Parkinson's
  x-tosis has been awarded a $2.74M grant from The Michael J. Fox Foundation to advance XTS001, an oral, brain-penetrant molecule that blocks VDAC1 oligomerization, toward Parkinson's development.
• news · 22 Jun 2026 Review: forcing ER-to-mitochondria calcium overload through the IP3R–GRP75–VDAC1 relay as a way to kill cancer cells
  A Yantai University review maps calcium overload as a cancer-killing strategy, how the ER and mitochondria trade calcium across their contact sites, with VDAC1 sitting in the middle of the relay.
• news · 15 Jun 2026 Bladder cancer resists cisplatin by tagging VDAC1 for mitophagy, blocking that pathway restores the drug's punch
  A Southern Medical University team found bladder-cancer cells survive cisplatin by tagging VDAC1 for destruction and switching on mitophagy, block that escape hatch and the drug bites again.
• news · 26 May 2026 In uveal melanoma, VDAC1 helps keep the tumour's genome stable, silencing it kills cells and unleashes DNA damage
  Screening uveal melanoma for genes tied to DNA–RNA tangles, a Yichang team found VDAC1 near the top, and switching it off both killed tumour cells and scrambled their genome.

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