#VDAC1

• news · 22 Jul 2026 In septic T cells, VDAC1 oligomers open a pore that leaks mtDNA and drives inflammation — and VBIT-12 shuts it down
  A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells — and calmed the whole thing down with the oligomerization blocker VBIT-12.
• explainer · 12 Jul 2026 So what actually is VDAC1, and why do I care this much?
  The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it — with a spin-it-yourself 3D structure.
• drug-watch · 8 Jul 2026 VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
  A running summary of the VBIT compounds that block VDAC1 oligomerization — where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.
• personal · 3 Jul 2026 Why a PSEN1 carrier ended up obsessed with mitochondria
  The origin story of this blog — a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for.
• news · 24 Jun 2026 x-tosis lands a $2.74M Michael J. Fox Foundation grant to push XTS001 — a brain-penetrant VDAC1-oligomerization blocker — toward Parkinson's
  The most conflicted post on the site, flagged as such: x-tosis — the biotech I co-founded — just won a $2.74M grant from The Michael J. Fox Foundation to advance XTS001, an oral, brain-penetrant molecule that blocks VDAC1 oligomerization, into Parkinson's development.
• news · 22 Jun 2026 Review: forcing ER-to-mitochondria calcium overload through the IP3R–GRP75–VDAC1 relay as a way to kill cancer cells
  A Yantai University review maps calcium overload as a cancer-killing strategy — how the ER and mitochondria trade calcium across their contact sites, with VDAC1 sitting in the middle of the relay.
• news · 15 Jun 2026 Bladder cancer resists cisplatin by tagging VDAC1 for mitophagy — blocking that pathway restores the drug's punch
  A Southern Medical University team found bladder-cancer cells survive cisplatin by tagging VDAC1 for destruction and switching on mitophagy — block that escape hatch and the drug bites again.
• news · 26 May 2026 In uveal melanoma, VDAC1 helps keep the tumour's genome stable — silencing it kills cells and unleashes DNA damage
  Screening uveal melanoma for genes tied to DNA–RNA tangles, a Yichang team found VDAC1 near the top — and switching it off both killed tumour cells and scrambled their genome.

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