Mitochondrial clinical trials — ilovemitochondria.com

Not medical advice and not a complete list. Trial statuses and details change — the ClinicalTrials.gov record is the source of truth. Talk to a clinician about trials relevant to you.

NCT06373731 ↗ Phase 3Active, not recruiting

ReNEW: Elamipretide in dry age-related macular degeneration

Elamipretide (SS-31) · Stealth BioTherapeutics

MoAMembrane / cardiolipinOphthalmology / AMD

NCT03323749 ↗ Phase 3Terminated

Elamipretide in primary mitochondrial myopathy (MMPOWER-3)

Elamipretide (SS-31) · Stealth BioTherapeutics

MoAMembrane / cardiolipinPrimary mitochondrial disease

NCT03056209 ↗ Phase 1Completed

KL1333 single-ascending-dose study in mitochondrial disease

KL1333 (NAD+ modulator) · Abliva / Yungjin

MoANAD+ / redoxPrimary mitochondrial disease

NCT07298005 ↗ Phase 2Recruiting

SON4PEM: Sonlicromanol in post-COVID condition

Sonlicromanol (KH176) · Khondrion (investigator-led)

MoANAD+ / redoxAntioxidant / oxidative stressPost-viral / fatigue

NCT05485987 ↗ Phase 2Completed

Vatiquinone in young children with Friedreich ataxia

Vatiquinone (EPI-743) · PTC Therapeutics

MoAAntioxidant / oxidative stressFriedreich's ataxia

NCT03845712 ↗ Phase 2Active, not recruiting

Pyrimidine nucleosides in TK2 deficiency

Doxecitine + doxribtimine (MT1621) · UCB (ex-Modis/Zogenix)

MoANucleoside substrateRare pediatric mitochondrial disease

NCT06474104 ↗ ObservationalRecruiting

Minovia mitochondrial augmentation — biomarker collection

Mitochondrial augmentation therapy (MAT) · Minovia Therapeutics

MoAMitochondrial transplant / cell therapyPrimary mitochondrial disease

NCT04151472 ↗ Phase 3Recruiting

Idebenone for prevention of episodic migraine

Idebenone (CoQ10 analog) · Zhejiang University

MoAAntioxidant / oxidative stressNeurology / migraine

Clinical trials