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news · 4 Aug 2026
Losing the mitochondrial quality-control genes HtrA2 or PINK1 makes cells more likely to turn senescent after DNA damage
A De Montfort University team knocked out three separate mitochondrial quality-control genes in mouse cells and found that losing HtrA2 or the mitophagy regulator PINK1 made cells noticeably more prone to senescence after DNA-damaging drugs, while the DNA damage response itself didn't fully explain which cells actually became senescent.
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news · 10 Jul 2026
A mitochondria-targeting nanozyme restarts mitophagy in cartilage and switches off mtDNA-driven inflammation in osteoarthritis
Bioengineers at Shanghai Ninth People's Hospital built a mitochondria-targeting nanozyme that mops up damage in cartilage cells, restarts mitophagy, and shuts down the mtDNA→cGAS/STING inflammation loop in osteoarthritis.
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news · 26 Jun 2026
Danshen (Salvia miltiorrhiza) eases lung fibrosis in rats by restoring PINK1/Parkin mitophagy in fibroblasts
A Shanghai team showed danshen (Salvia miltiorrhiza) eases lung fibrosis in rats by nudging fibroblasts to run mitophagy through the PINK1/Parkin pathway.
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news · 15 Jun 2026
Bladder cancer resists cisplatin by tagging VDAC1 for mitophagy, blocking that pathway restores the drug's punch
A Southern Medical University team found bladder-cancer cells survive cisplatin by tagging VDAC1 for destruction and switching on mitophagy, block that escape hatch and the drug bites again.
