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news · 22 Jun 2026
Review: forcing ER-to-mitochondria calcium overload through the IP3R–GRP75–VDAC1 relay as a way to kill cancer cells
A Yantai University review maps calcium overload as a cancer-killing strategy — how the ER and mitochondria trade calcium across their contact sites, with VDAC1 sitting in the middle of the relay.
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news · 15 Jun 2026
Bladder cancer resists cisplatin by tagging VDAC1 for mitophagy — blocking that pathway restores the drug's punch
A Southern Medical University team found bladder-cancer cells survive cisplatin by tagging VDAC1 for destruction and switching on mitophagy — block that escape hatch and the drug bites again.
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news · 26 May 2026
In uveal melanoma, VDAC1 helps keep the tumour's genome stable — silencing it kills cells and unleashes DNA damage
Screening uveal melanoma for genes tied to DNA–RNA tangles, a Yichang team found VDAC1 near the top — and switching it off both killed tumour cells and scrambled their genome.
