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news · 4 Aug 2026
Losing the mitochondrial quality-control genes HtrA2 or PINK1 makes cells more likely to turn senescent after DNA damage
A De Montfort University team knocked out three separate mitochondrial quality-control genes in mouse cells and found that losing HtrA2 or the mitophagy regulator PINK1 made cells noticeably more prone to senescence after DNA-damaging drugs, while the DNA damage response itself didn't fully explain which cells actually became senescent.
