So what actually is VDAC1, and why do I care this much?
The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it, with a spin-it-yourself 3D structure.
read →VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
A running summary of the VBIT compounds that block VDAC1 oligomerization, where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.
read →Why a PSEN1 carrier ended up obsessed with mitochondria
The origin story of this blog, a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for.
read →