So what actually is VDAC1, and why do I care this much?
The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it — with a spin-it-yourself 3D structure.
read →VBIT-4 & VBIT-12: the molecules trying to stop VDAC1 from ganging up
A running summary of the VBIT compounds that block VDAC1 oligomerization — where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is.
read →Why a PSEN1 carrier ended up obsessed with mitochondria
The origin story of this blog — a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for.
read →