https://ilovemitochondria.com/ A personal blog by Offer Shina about mitochondria and VDAC1 — the science, the news, and why a PSEN1 carrier can't stop reading about it. en https://ilovemitochondria.com/news/vdac1-tcell-inflammation/ https://ilovemitochondria.com/news/vdac1-tcell-inflammation/ Wed, 22 Jul 2026 00:00:00 GMT A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells — and calmed the whole thing down with the oligomerization blocker VBIT-12. VDAC1inflammationmtDNAcGAS-STINGVBITsepsis https://ilovemitochondria.com/posts/what-is-vdac1/ https://ilovemitochondria.com/posts/what-is-vdac1/ Sun, 12 Jul 2026 00:00:00 GMT The on-ramp post: what the channel does, why 'the most abundant protein on the mitochondrial outer membrane' is a big deal, and how the same pore that keeps a cell alive can help kill it — with a spin-it-yourself 3D structure. VDAC1mitochondriaexplainerVBIT https://ilovemitochondria.com/news/osteoarthritis-nanozyme/ https://ilovemitochondria.com/news/osteoarthritis-nanozyme/ Fri, 10 Jul 2026 00:00:00 GMT Bioengineers at Shanghai Ninth People's Hospital built a mitochondria-targeting nanozyme that mops up damage in cartilage cells, restarts mitophagy, and shuts down the mtDNA→cGAS/STING inflammation loop in osteoarthritis. mitophagymtDNAcGAS-STINGnanomedicine https://ilovemitochondria.com/news/kidney-mitochondria-genes/ https://ilovemitochondria.com/news/kidney-mitochondria-genes/ Wed, 08 Jul 2026 00:00:00 GMT A Sichuan group cross-referenced the whole MitoCarta gene inventory against genetics of acute and chronic kidney disease and pulled out a handful of mitochondrial genes that look causal. mitochondriageneticskidney https://ilovemitochondria.com/posts/vbit-4-and-vbit-12/ https://ilovemitochondria.com/posts/vbit-4-and-vbit-12/ Wed, 08 Jul 2026 00:00:00 GMT A running summary of the VBIT compounds that block VDAC1 oligomerization — where the idea came from, which disease models they've been tested in, and the honest caveats about how early it all still is. VBITVDAC1mtDNAdrug-watch https://ilovemitochondria.com/posts/why-this-blog/ https://ilovemitochondria.com/posts/why-this-blog/ Fri, 03 Jul 2026 00:00:00 GMT The origin story of this blog — a genetic result, the amyloid-vs-energy argument in Alzheimer's, and the hunch that mitochondria are doing more of the driving than we give them credit for. personalmitochondrianeurodegenerationVDAC1 https://ilovemitochondria.com/news/salvia-lung-fibrosis/ https://ilovemitochondria.com/news/salvia-lung-fibrosis/ Fri, 26 Jun 2026 00:00:00 GMT A Shanghai team showed danshen (Salvia miltiorrhiza) eases lung fibrosis in rats by nudging fibroblasts to run mitophagy through the PINK1/Parkin pathway. mitophagyPINK1-Parkinfibrosis https://ilovemitochondria.com/news/x-tosis-mjff-grant/ https://ilovemitochondria.com/news/x-tosis-mjff-grant/ Wed, 24 Jun 2026 00:00:00 GMT The most conflicted post on the site, flagged as such: x-tosis — the biotech I co-founded — just won a $2.74M grant from The Michael J. Fox Foundation to advance XTS001, an oral, brain-penetrant molecule that blocks VDAC1 oligomerization, into Parkinson's development. VDAC1VBITneurodegenerationParkinson'sx-tosiscompany https://ilovemitochondria.com/news/calcium-er-mito-review/ https://ilovemitochondria.com/news/calcium-er-mito-review/ Mon, 22 Jun 2026 00:00:00 GMT A Yantai University review maps calcium overload as a cancer-killing strategy — how the ER and mitochondria trade calcium across their contact sites, with VDAC1 sitting in the middle of the relay. VDAC1calciumcancerreview https://ilovemitochondria.com/news/bladder-cancer-mitophagy/ https://ilovemitochondria.com/news/bladder-cancer-mitophagy/ Mon, 15 Jun 2026 00:00:00 GMT A Southern Medical University team found bladder-cancer cells survive cisplatin by tagging VDAC1 for destruction and switching on mitophagy — block that escape hatch and the drug bites again. VDAC1mitophagycancer https://ilovemitochondria.com/news/vdac1-uveal-melanoma/ https://ilovemitochondria.com/news/vdac1-uveal-melanoma/ Tue, 26 May 2026 00:00:00 GMT Screening uveal melanoma for genes tied to DNA–RNA tangles, a Yichang team found VDAC1 near the top — and switching it off both killed tumour cells and scrambled their genome. VDAC1cancergenome-stability