/* =========================================================
   ilovemitochondria.com — light "young techno / old-school zine"
   white paper, hard offset shadows, mono accents, hand-made bits
   ========================================================= */

:root{
  --ink:#17171e; --ink-soft:#4a4a58; --paper:#ffffff; --cream:#faf6ee; --line:#17171e;
  --teal:#0e9488; --coral:#f0603a; --pink:#e5397f; --amber:#f5a524; --violet:#6b4df0;
  --shadow:5px 5px 0 var(--ink); --shadow-sm:3px 3px 0 var(--ink);
  --maxw:940px;
  --disp:"Space Grotesk","Segoe UI",system-ui,sans-serif;
  --mono:"Space Mono",ui-monospace,"Cascadia Code",Consolas,monospace;
  --body:"Space Grotesk",-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,sans-serif;
}
*{box-sizing:border-box;}
html{scroll-behavior:smooth;}
body{margin:0;background:var(--paper);color:var(--ink);font-family:var(--body);font-size:17px;line-height:1.68;-webkit-font-smoothing:antialiased;}
a{color:var(--teal);text-decoration:none;}
a:hover{text-decoration:underline;text-decoration-thickness:2px;text-underline-offset:3px;}
.wrap{max-width:var(--maxw);margin:0 auto;padding:0 22px;}

/* header */
.site-header{border-bottom:3px solid var(--line);background:var(--paper);position:sticky;top:0;z-index:40;}
.site-header .wrap{display:flex;align-items:center;justify-content:space-between;flex-wrap:wrap;gap:10px;padding:14px 22px;}
.brand{font-family:var(--disp);font-weight:700;font-size:1.3rem;letter-spacing:-0.5px;color:var(--ink);display:inline-flex;align-items:center;gap:8px;}
.brand:hover{text-decoration:none;}
.brand .heart{color:var(--coral);}
.brand .tld{color:var(--ink-soft);font-weight:400;font-family:var(--mono);font-size:0.95rem;}
nav.main{display:flex;align-items:center;flex-wrap:wrap;gap:2px;}
/* consistent box in every state → no reflow/jump on hover */
nav.main a{font-family:var(--mono);color:var(--ink);font-weight:400;font-size:0.9rem;padding:5px 9px;border:2px solid transparent;line-height:1;white-space:nowrap;}
nav.main a:hover,nav.main a.active{color:var(--paper);background:var(--ink);text-decoration:none;}
.nav-toggle{display:none;}

/* hero */
.hero{border-bottom:3px solid var(--line);background:var(--cream);}
.hero .wrap{display:grid;grid-template-columns:1.25fr 1fr;gap:34px;align-items:center;padding:52px 22px;}
.eyebrow{font-family:var(--mono);font-size:0.8rem;text-transform:uppercase;letter-spacing:1.5px;color:var(--teal);margin:0 0 12px;}
.hero h1{font-family:var(--disp);font-weight:700;font-size:2.7rem;line-height:1.06;letter-spacing:-1.4px;margin:0 0 16px;}
.hero h1 .u{background-image:url("../images/underline.svg");background-repeat:no-repeat;background-position:0 1.05em;background-size:100% 0.35em;padding-bottom:2px;}
.hero p.lead{font-size:1.12rem;color:var(--ink-soft);margin:0 0 22px;}
.hero-art{text-align:center;}
.hero-art img{width:100%;max-width:380px;}

.tagpills{display:flex;flex-wrap:wrap;gap:9px;}
.pill{font-family:var(--mono);font-size:0.74rem;text-transform:uppercase;letter-spacing:0.5px;background:var(--paper);border:2px solid var(--line);color:var(--ink);padding:4px 10px;border-radius:999px;}
.pill.t1{background:#d6f5f0;} .pill.t2{background:#ffe0d6;} .pill.t3{background:#ffeecb;} .pill.t4{background:#f0ebff;}
a.pill{cursor:pointer;transition:transform .1s,box-shadow .1s;}
a.pill:hover{text-decoration:none;color:#fff;background:var(--ink);border-color:var(--ink);box-shadow:var(--shadow-sm);transform:translateY(-1px);}

/* sections */
main{padding:46px 0 80px;}
section{margin-bottom:52px;}
h2{font-family:var(--disp);font-weight:700;font-size:1.7rem;letter-spacing:-0.6px;margin:0 0 6px;display:inline-block;}
h2 .num{font-family:var(--mono);font-size:1rem;color:var(--coral);font-weight:700;margin-right:8px;}
.section-sub{color:var(--ink-soft);margin:0 0 24px;}
.rule{height:3px;background:var(--ink);border:0;margin:0 0 26px;}

/* sticker */
.sticker{display:inline-block;font-family:var(--mono);font-size:0.72rem;font-weight:700;text-transform:uppercase;letter-spacing:0.5px;padding:3px 9px;border:2px solid var(--line);box-shadow:var(--shadow-sm);background:var(--amber);transform:rotate(-2deg);margin-bottom:12px;}
.sticker.teal{background:var(--teal);color:#fff;} .sticker.pink{background:var(--pink);color:#fff;} .sticker.violet{background:var(--violet);color:#fff;}
.sticker.rot{transform:rotate(2deg);}

/* generic card */
.card{background:var(--paper);border:3px solid var(--line);box-shadow:var(--shadow);padding:22px 24px;margin-bottom:26px;transition:box-shadow .12s ease,transform .12s ease;}
.card:hover{box-shadow:8px 8px 0 var(--ink);transform:translate(-1px,-1px);}
.meta{font-family:var(--mono);font-size:0.76rem;color:var(--ink-soft);margin-bottom:8px;display:flex;gap:12px;flex-wrap:wrap;}
.card h3{font-family:var(--disp);font-weight:700;margin:0 0 10px;font-size:1.35rem;line-height:1.2;letter-spacing:-0.4px;}
.card h3 a{color:var(--ink);} .card h3 a:hover{color:var(--teal);text-decoration:none;}
.readmore{font-family:var(--mono);font-weight:700;font-size:0.85rem;color:var(--coral);}
.src{font-family:var(--mono);font-size:0.78rem;} .src a{color:var(--ink-soft);}

/* NEWS varied formats */
.n-feature{display:grid;grid-template-columns:1fr 300px;gap:0;border:3px solid var(--line);box-shadow:var(--shadow);margin-bottom:30px;background:var(--paper);}
.n-feature .body{padding:26px 28px;}
.n-feature .art{background:var(--cream);border-left:3px solid var(--line);display:flex;align-items:center;justify-content:center;padding:18px;}
.n-feature .art img{width:100%;}
.n-feature h3{font-size:1.7rem;line-height:1.12;margin:6px 0 12px;letter-spacing:-0.7px;font-family:var(--disp);font-weight:700;}
.n-feature h3 a{color:var(--ink);} .n-feature p{font-size:1.02rem;}
.n-brief{border-left:6px solid var(--teal);padding:4px 0 4px 20px;margin:0 0 26px;}
.n-brief.pink{border-color:var(--pink);} .n-brief.violet{border-color:var(--violet);}
.n-brief h3{font-family:var(--disp);font-weight:700;font-size:1.25rem;margin:0 0 8px;letter-spacing:-0.3px;} .n-brief h3 a{color:var(--ink);}
.n-oneliner{font-family:var(--mono);font-size:0.95rem;border-bottom:2px dotted #cfc9bd;padding:12px 0;display:flex;gap:14px;align-items:baseline;}
.n-oneliner .tick{color:var(--coral);font-weight:700;white-space:nowrap;}
.n-quickbox{background:var(--cream);border:3px solid var(--line);box-shadow:var(--shadow);padding:22px 26px;margin:0 0 30px;}
.n-quickbox h3{font-family:var(--disp);font-weight:700;margin:0 0 6px;font-size:1.3rem;}
.n-quickbox ol{margin:14px 0 0;padding-left:0;list-style:none;counter-reset:qh;}
.n-quickbox li{counter-increment:qh;padding:12px 0;border-top:2px solid #e4ddce;}
.n-quickbox li::before{content:counter(qh);font-family:var(--mono);font-weight:700;color:var(--paper);background:var(--ink);padding:1px 8px;margin-right:10px;}
.n-aside{background:#fff8e6;border:2px dashed var(--amber);padding:18px 22px;margin:0 0 30px;}
.n-aside .lbl{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;letter-spacing:1px;color:var(--amber);font-weight:700;}

/* chips (tags) */
.chips{display:flex;flex-wrap:wrap;gap:8px;margin:8px 0;}
.chip{font-family:var(--mono);font-size:0.72rem;text-transform:lowercase;letter-spacing:0.3px;background:var(--paper);border:2px solid var(--line);color:var(--ink);padding:3px 10px;border-radius:999px;}
.chip:hover{background:var(--ink);color:var(--paper);text-decoration:none;}
.chip::before{content:"#";opacity:0.5;}

/* article */
article.full{max-width:760px;}
.breadcrumb{font-family:var(--mono);font-size:0.78rem;color:var(--ink-soft);margin-bottom:14px;}
.breadcrumb a{color:var(--ink-soft);}
article.full .kicker{font-family:var(--mono);font-size:0.8rem;text-transform:uppercase;letter-spacing:1px;color:var(--teal);}
article.full h1{font-family:var(--disp);font-weight:700;font-size:2.3rem;line-height:1.1;letter-spacing:-1px;margin:8px 0 12px;}
article.full h2{font-family:var(--disp);font-weight:700;font-size:1.5rem;margin:36px 0 4px;letter-spacing:-0.5px;}
article.full h3{font-family:var(--disp);font-weight:700;font-size:1.2rem;margin:26px 0 2px;}
article.full p,article.full li{color:#26262f;}
article.full figure{margin:26px 0;text-align:center;}
article.full figure img{width:100%;max-width:460px;border:3px solid var(--line);box-shadow:var(--shadow);background:var(--cream);}
article.full figcaption{font-family:var(--mono);font-size:0.78rem;color:var(--ink-soft);margin-top:10px;}
article.full blockquote{border-left:6px solid var(--coral);margin:22px 0;padding:8px 20px;font-family:var(--disp);font-size:1.2rem;font-weight:500;color:var(--ink);}
.backlink{font-family:var(--mono);font-size:0.85rem;color:var(--ink-soft);display:inline-block;margin-bottom:20px;}

/* source box on article */
.sourcebox{font-family:var(--mono);font-size:0.82rem;background:var(--cream);border:2px solid var(--line);padding:14px 18px;margin:24px 0;}
.sourcebox b{font-family:var(--disp);}

/* related / more-about */
.moreabout{border-top:3px solid var(--line);margin-top:44px;padding-top:24px;}
.moreabout h2{font-size:1.3rem;}
.related-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px;margin-top:16px;}
.related-item{border:2px solid var(--line);padding:14px 16px;background:var(--paper);}
.related-item:hover{box-shadow:var(--shadow-sm);}
.related-item .k{font-family:var(--mono);font-size:0.7rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--coral);}
.related-item a{font-family:var(--disp);font-weight:700;color:var(--ink);display:block;margin-top:3px;line-height:1.25;}
.related-item a:hover{color:var(--teal);}

/* 3D viewer */
.viewer-wrap{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--cream);}
.viewer-bar{font-family:var(--mono);font-size:0.75rem;padding:8px 14px;border-bottom:3px solid var(--line);background:var(--ink);color:var(--paper);display:flex;justify-content:space-between;}
#vdac-3d{width:100%;height:420px;position:relative;}
.viewer-fallback{font-family:var(--mono);font-size:0.82rem;color:var(--ink-soft);padding:16px;text-align:center;}

/* resources */
.res-group{margin-bottom:34px;}
.res-group h3{font-family:var(--disp);font-weight:700;font-size:1.2rem;margin:0 0 4px;}
.res-group .rlabel{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;letter-spacing:1px;color:var(--coral);}
.res-list{list-style:none;padding:0;margin:14px 0 0;display:grid;gap:0;border-top:2px solid var(--ink);}
.res-item{padding:14px 4px;border-bottom:2px solid #e6e0d3;}
.res-item:hover{background:var(--cream);}
.res-item a{font-family:var(--disp);font-weight:700;font-size:1.02rem;color:var(--ink);} .res-item a:hover{color:var(--teal);}
.res-item .desc{color:var(--ink-soft);font-size:0.92rem;margin-top:2px;}

/* about */
.about-grid{display:grid;grid-template-columns:1fr 260px;gap:34px;align-items:start;}
.about-body p{margin:0 0 16px;}
.about-body h2{font-family:var(--disp);font-weight:700;margin:30px 0 6px;font-size:1.45rem;letter-spacing:-0.4px;}
.about-card{border:3px solid var(--line);box-shadow:var(--shadow);padding:0;position:sticky;top:90px;}
.about-card img{width:100%;display:block;border-bottom:3px solid var(--line);background:var(--cream);}
.about-card .info{padding:16px 18px;font-family:var(--mono);font-size:0.82rem;}
.about-card .info b{font-family:var(--disp);font-size:1.05rem;}
.callout{background:var(--cream);border:2px solid var(--line);border-left:6px solid var(--amber);padding:16px 20px;margin:22px 0;}
.callout strong{color:var(--ink);}

/* tag pages */
.tagcloud{display:flex;flex-wrap:wrap;gap:10px;margin-top:18px;}
.tagcloud a{font-family:var(--mono);border:2px solid var(--line);padding:6px 12px;background:var(--paper);color:var(--ink);box-shadow:var(--shadow-sm);}
.tagcloud a:hover{background:var(--ink);color:var(--paper);text-decoration:none;}
.tagcloud a .c{color:var(--coral);font-weight:700;}
.taglist{list-style:none;padding:0;margin:20px 0 0;}
.taglist li{border-top:2px solid #e6e0d3;padding:16px 0;}
.taglist li:last-child{border-bottom:2px solid #e6e0d3;}
.taglist .k{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;color:var(--coral);letter-spacing:0.5px;}
.taglist a.title{font-family:var(--disp);font-weight:700;font-size:1.2rem;color:var(--ink);display:block;margin:2px 0 4px;} .taglist a.title:hover{color:var(--teal);}
.taglist .d{color:var(--ink-soft);font-size:0.92rem;}

/* footer */
.site-footer{border-top:3px solid var(--line);background:var(--ink);color:#cfcfe0;padding:30px 0 44px;font-family:var(--mono);font-size:0.86rem;}
.site-footer a{color:#fff;}
.site-footer .fnav{margin-bottom:10px;} .site-footer .fnav a{margin-right:16px;}
.site-footer .small{margin-top:12px;font-size:0.76rem;color:#9a9ab5;line-height:1.6;}

@media (max-width:760px){
  .hero .wrap{grid-template-columns:1fr;} .hero-art{order:-1;}
  .n-feature{grid-template-columns:1fr;} .n-feature .art{border-left:0;border-top:3px solid var(--line);}
  .about-grid{grid-template-columns:1fr;} .about-card{position:static;max-width:320px;}
  .related-grid{grid-template-columns:1fr;} .hero h1{font-size:2.1rem;}
}
/* ===== mitochondrial health ratings — its own look ===== */
.mh-hero{background:linear-gradient(120deg,#eef7f5,#f3f0ff);}
.mh-hero-solo .wrap{grid-template-columns:1fr;}
.mh-herostat{font-family:var(--mono);font-size:0.86rem;color:var(--ink);margin:14px 0 0;border-top:2px solid var(--line);padding-top:12px;display:inline-block;}
.mh-herostat b{color:var(--teal);font-size:1.05rem;}
.mh-method{border:2px solid var(--line);background:var(--paper);margin-bottom:20px;}
.mh-method summary{font-family:var(--mono);font-size:0.85rem;font-weight:700;padding:12px 16px;cursor:pointer;}
.mh-method p{padding:0 16px;color:var(--ink-soft);font-size:0.92rem;}
.mh-legend{padding:6px 16px 16px;display:grid;gap:8px;}
.mh-legend .lgd{font-family:var(--mono);font-size:0.7rem;text-transform:uppercase;letter-spacing:1px;color:var(--ink-soft);margin-right:8px;}
.mh-filters{flex-direction:column;align-items:stretch;}
.mh-filters .fgrow{width:100%;}
#mhsearch{width:100%;font-family:var(--mono);font-size:0.9rem;border:2px solid var(--line);padding:9px 12px;background:var(--paper);}
#mhmech{font-family:var(--mono);font-size:0.8rem;border:2px solid var(--line);background:var(--paper);padding:4px 8px;}

.mh-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(300px,1fr));gap:16px;}
.mh-card{border:2px solid var(--line);background:var(--paper);padding:16px 18px;border-top:6px solid var(--teal);}
.mh-card:hover{box-shadow:var(--shadow-sm);}
.mh-card.dir-harm{border-top-color:var(--coral);background:#fff7f5;}
.mh-card.dir-mixed{border-top-color:var(--amber);}
.mh-top{display:flex;justify-content:space-between;align-items:center;gap:8px;}
.mh-cat{font-family:var(--mono);font-size:0.68rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--ink-soft);}
.mh-harm{font-family:var(--mono);font-size:0.64rem;font-weight:700;text-transform:uppercase;background:var(--coral);color:#fff;padding:1px 6px;}
.mh-mixed{font-family:var(--mono);font-size:0.64rem;font-weight:700;text-transform:uppercase;background:var(--amber);color:#3a2f10;padding:1px 6px;}
.mh-card h3{font-family:var(--disp);font-weight:700;font-size:1.14rem;margin:6px 0 3px;line-height:1.2;}
.mh-mech{font-family:var(--mono);font-size:0.74rem;color:var(--teal);margin-bottom:10px;}
.mh-card.dir-harm .mh-mech{color:var(--coral);}
.mh-card p{font-size:0.88rem;margin:10px 0;color:#2b2b34;}
.mh-links{display:flex;flex-direction:column;gap:4px;font-family:var(--mono);font-size:0.75rem;}

.dials{display:flex;flex-wrap:wrap;gap:6px;}
.dial{font-family:var(--mono);font-size:0.7rem;padding:2px 8px;border:1.5px solid var(--line);border-radius:3px;white-space:nowrap;}
.dial b{font-weight:700;opacity:0.55;margin-right:5px;text-transform:uppercase;font-size:0.62rem;}
/* evidence */
.ev-strong{background:#c9f2d8;} .ev-moderate{background:#d6f5f0;} .ev-preliminary{background:#fdeecb;} .ev-weak{background:#ececec;} .ev-mixed{background:#ece4ff;}
/* benefit */
.ben-high{background:#c9f2d8;} .ben-moderate{background:#d6f5f0;} .ben-low{background:#ececec;} .ben-harmful{background:#ffd9d2;}
/* safety */
.saf-high{background:#c9f2d8;} .saf-moderate{background:#fdeecb;} .saf-caution{background:#ffe2c2;} .saf-low{background:#ffd9d2;}
.mh-foot{font-family:var(--mono);font-size:0.78rem;color:var(--ink-soft);border-top:2px dashed var(--line);margin-top:26px;padding-top:14px;}

@media (max-width:560px){ .mh-grid{grid-template-columns:1fr;} }

/* ===== hero CTA buttons ===== */
.hero-cta{display:flex;flex-wrap:wrap;gap:12px;margin:22px 0 4px;}
.btn-primary{font-family:var(--disp);font-weight:700;font-size:0.98rem;background:var(--teal);color:#fff;border:3px solid var(--line);box-shadow:var(--shadow-sm);padding:11px 20px;transition:transform .12s,box-shadow .12s;}
.btn-primary:hover{transform:translate(-2px,-2px);box-shadow:var(--shadow);text-decoration:none;color:#fff;}
.btn-ghost{font-family:var(--mono);font-weight:700;font-size:0.9rem;color:var(--ink);border:3px solid var(--line);padding:11px 18px;background:var(--paper);}
.btn-ghost:hover{background:var(--ink);color:var(--paper);text-decoration:none;}

/* ===== flagship (mito-health ratings) on home ===== */
.flagship{margin-bottom:40px;}
.flag-card{display:grid;grid-template-columns:1fr auto;gap:24px;align-items:center;border:3px solid var(--line);box-shadow:7px 7px 0 var(--teal);background:linear-gradient(120deg,#eef7f5,#f3f0ff);padding:28px 30px;color:var(--ink);transition:transform .12s,box-shadow .12s;}
.flag-card:hover{transform:translate(-2px,-2px);box-shadow:10px 10px 0 var(--teal);text-decoration:none;}
.flag-tag{font-family:var(--mono);font-size:0.72rem;font-weight:700;text-transform:uppercase;letter-spacing:1px;color:var(--coral);}
.flag-body h2{font-family:var(--disp);font-weight:700;font-size:1.9rem;letter-spacing:-0.6px;margin:8px 0 10px;display:block;}
.flag-body p{color:#2b2b34;margin:0 0 14px;max-width:60ch;}
.flag-cta{font-family:var(--mono);font-weight:700;font-size:0.95rem;color:var(--teal);}
.flag-stat{text-align:center;border-left:3px solid var(--line);padding-left:24px;}
.flag-stat b{font-family:var(--disp);font-weight:700;font-size:3.4rem;line-height:1;color:var(--teal);display:block;}
.flag-stat span{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--ink-soft);}
@media (max-width:640px){ .flag-card{grid-template-columns:1fr;} .flag-stat{border-left:0;border-top:3px solid var(--line);padding-left:0;padding-top:14px;} .flag-body h2{font-size:1.5rem;} }

/* flagship nav item */
nav.main a.nav-feature{background:var(--teal);color:#fff;font-weight:700;}
nav.main a.nav-feature:hover,nav.main a.nav-feature.active{background:var(--ink);color:#fff;}

/* ===== home sitemap teasers ===== */
.sitemap-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(240px,1fr));gap:16px;}
.teaser{position:relative;display:flex;flex-direction:column;border:3px solid var(--line);background:var(--paper);box-shadow:var(--shadow-sm);padding:18px 20px;color:var(--ink);transition:transform .12s ease,box-shadow .12s ease;}
.teaser:hover{transform:translate(-2px,-2px);box-shadow:var(--shadow);text-decoration:none;border-color:var(--teal);}
.teaser-ico{font-size:1.5rem;line-height:1;color:var(--teal);}
.teaser-meta{font-family:var(--mono);font-size:0.68rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--coral);font-weight:700;margin:8px 0 2px;}
.teaser h3{font-family:var(--disp);font-weight:700;font-size:1.14rem;margin:0 0 6px;line-height:1.2;}
.teaser p{font-size:0.88rem;color:var(--ink-soft);margin:0 0 12px;flex:1;}
.teaser-go{font-family:var(--mono);font-size:0.78rem;font-weight:700;color:var(--teal);}
.teaser:nth-child(1){border-top:6px solid var(--teal);}
.teaser:nth-child(4n+2){border-top:6px solid var(--coral);}
.teaser:nth-child(4n+3){border-top:6px solid var(--amber);}
.teaser:nth-child(4n+4){border-top:6px solid var(--violet);}

/* ===== wide layout for data/filter pages ===== */
/* widen only the hero + main content (not header/footer, so nav stays put) */
body.wide .hero > .wrap,
body.wide main > .wrap{ max-width:1320px; }

/* ===== sidebar filter layout ===== */
.sidebar-wrap{display:grid;grid-template-columns:260px minmax(0,1fr);gap:32px;align-items:start;}
.sidebar{position:sticky;top:88px;}
.sidebar .filters{flex-direction:column;align-items:stretch;gap:16px;margin-bottom:0;padding:16px;}
.sidebar .fgroup{flex-direction:column;align-items:flex-start;gap:7px;width:100%;}
.sidebar .flabel{font-size:0.68rem;}
.fchips{display:flex;flex-wrap:wrap;gap:6px;}
.filter-toggle{display:none;}

/* tablet: keep sidebar but a touch narrower */
@media (max-width:1024px){
  .sidebar-wrap{grid-template-columns:220px minmax(0,1fr);gap:24px;}
}
/* mobile: sidebar collapses behind a toggle, full-width when open */
@media (max-width:820px){
  .sidebar-wrap{grid-template-columns:1fr;gap:0;}
  .sidebar{position:static;width:100%;}
  .filter-toggle{display:inline-flex;align-items:center;gap:8px;font-family:var(--mono);font-weight:700;font-size:0.9rem;border:2px solid var(--line);background:var(--cream);padding:10px 16px;box-shadow:var(--shadow-sm);cursor:pointer;margin-bottom:16px;width:100%;justify-content:center;}
  .filter-toggle.open{background:var(--ink);color:var(--paper);}
  .sidebar .filters{display:none;margin-bottom:18px;}
  .sidebar.open .filters{display:flex;}
}

/* ===== global search ===== */
.nav-search{font-family:var(--mono);font-size:0.82rem;border:2px solid var(--line);background:var(--paper);color:var(--ink);cursor:pointer;padding:3px 9px;margin-left:16px;display:inline-flex;align-items:center;gap:6px;}
.nav-search:hover{background:var(--ink);color:var(--paper);}
.kbd{font-family:var(--mono);font-size:0.68rem;border:1px solid currentColor;border-radius:3px;padding:0 4px;opacity:0.65;}
.ssearch{position:fixed;inset:0;background:rgba(20,20,25,0.42);z-index:200;display:flex;justify-content:center;align-items:flex-start;padding:12vh 16px 16px;}
.ssearch[hidden]{display:none;}
.ssearch-box{width:min(580px,94vw);background:var(--paper);border:3px solid var(--line);box-shadow:8px 8px 0 var(--ink);max-height:80vh;display:flex;flex-direction:column;}
#ss-input{width:100%;font-family:var(--disp);font-weight:500;font-size:1.15rem;border:0;border-bottom:3px solid var(--line);padding:16px 18px;outline:none;background:var(--paper);color:var(--ink);}
.ss-results{overflow-y:auto;}
.ss-item{display:flex;align-items:center;gap:10px;padding:11px 18px;border-bottom:1px solid #ece6d9;color:var(--ink);font-weight:500;}
.ss-item:hover,.ss-item.on{background:var(--cream);text-decoration:none;}
.ss-k{font-family:var(--mono);font-size:0.62rem;text-transform:uppercase;letter-spacing:0.5px;background:var(--ink);color:var(--paper);padding:1px 6px;white-space:nowrap;}
.ss-empty{padding:18px;font-family:var(--mono);font-size:0.85rem;color:var(--ink-soft);}
.ss-hint{font-family:var(--mono);font-size:0.7rem;color:var(--ink-soft);padding:9px 18px;border-top:2px solid var(--line);}
@media (max-width:560px){ .nav-search .kbd{display:none;} }

/* nav dropdown */
.hasmenu{position:relative;}
.hasmenu>a{font-family:var(--mono);color:var(--ink);font-weight:400;font-size:0.9rem;padding:5px 9px;border:2px solid transparent;display:inline-flex;align-items:center;gap:4px;line-height:1;white-space:nowrap;cursor:pointer;}
.hasmenu .caret{font-size:0.7rem;}
.hasmenu.active>a{color:var(--paper);background:var(--ink);}
.hasmenu>a:hover{color:var(--paper);background:var(--ink);text-decoration:none;}
/* invisible hover bridge so moving cursor into the menu doesn't drop it */
.hasmenu::after{content:"";position:absolute;top:100%;left:0;width:100%;height:8px;}
.submenu{position:absolute;top:calc(100% + 6px);left:0;min-width:240px;background:var(--paper);border:3px solid var(--line);box-shadow:var(--shadow);padding:6px;opacity:0;visibility:hidden;transform:translateY(-4px);transition:opacity .12s ease,transform .12s ease;z-index:50;}
.hasmenu:hover .submenu,.hasmenu:focus-within .submenu{opacity:1;visibility:visible;transform:translateY(0);}
.submenu a{display:block;font-family:var(--mono);font-size:0.85rem;color:var(--ink);padding:8px 10px;margin:0;border:0;white-space:nowrap;}
.submenu a:hover,.submenu a.active{background:var(--ink);color:var(--paper);text-decoration:none;}

/* disclaimer banner */
.disclaimer{font-family:var(--mono);font-size:0.82rem;background:#fff8e6;border:2px dashed var(--amber);padding:12px 16px;margin-bottom:22px;color:#6a5a2a;}

/* companies + trials cards */
.co-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(300px,1fr));gap:18px;}
.co-card,.tr-card{border:3px solid var(--line);box-shadow:var(--shadow-sm);background:var(--paper);padding:18px 20px;}
.co-card:hover,.tr-card:hover{box-shadow:var(--shadow);}
.co-highlight{border-color:var(--coral);box-shadow:5px 5px 0 var(--coral);background:#fff6f3;position:relative;}
.co-flag{display:inline-block;font-family:var(--mono);font-size:0.68rem;font-weight:700;text-transform:uppercase;letter-spacing:0.5px;background:var(--coral);color:#fff;padding:2px 8px;margin-bottom:8px;}
.co-head{display:flex;justify-content:space-between;align-items:baseline;gap:10px;flex-wrap:wrap;}
.co-head h3{font-family:var(--disp);font-weight:700;font-size:1.2rem;margin:0;}
.co-head h3 a{color:var(--ink);} .co-head h3 a:hover{color:var(--teal);}
.co-stage{font-family:var(--mono);font-size:0.72rem;font-weight:700;text-transform:uppercase;letter-spacing:0.5px;border:2px solid var(--line);padding:2px 8px;white-space:nowrap;background:#eef;}
.co-card p,.tr-card p{font-size:0.92rem;margin:10px 0;}
.co-rating{font-size:1rem;letter-spacing:2px;margin:4px 0 2px;}
.co-ratingnote{font-family:var(--mono);font-size:0.72rem;letter-spacing:0;color:var(--ink-soft);font-style:italic;}
.co-coi{font-family:var(--mono);font-size:0.78rem;background:#fff8e6;border-left:3px solid var(--amber);padding:8px 12px;color:#6a5a2a;}
.co-tax{display:flex;flex-wrap:wrap;gap:6px;align-items:center;margin-top:8px;}
.co-lbl{font-family:var(--mono);font-size:0.68rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--ink-soft);margin-right:2px;}
.chip2{font-family:var(--mono);font-size:0.72rem;background:#d6f5f0;border:1.5px solid var(--line);padding:2px 8px;border-radius:999px;}
.chip2.alt{background:#f0ebff;}
.exp-type{text-transform:uppercase;font-weight:700;letter-spacing:0.5px;}

/* trials specifics */
.tr-head{display:flex;gap:10px;align-items:center;flex-wrap:wrap;margin-bottom:4px;}
.tr-nct{font-family:var(--mono);font-weight:700;font-size:0.8rem;}
.tr-phase{font-family:var(--mono);font-size:0.7rem;border:2px solid var(--line);padding:1px 7px;background:#eef;}
.tr-status{font-family:var(--mono);font-size:0.7rem;padding:1px 7px;border:2px solid var(--line);}
.tr-status.ok{background:#d6f5e0;} .tr-status.bad{background:#ffdede;} .tr-status.neu{background:#f0efe8;}
.tr-card h3{font-family:var(--disp);font-weight:700;font-size:1.08rem;margin:6px 0 4px;line-height:1.25;}
.tr-card h3 a{color:var(--ink);} .tr-card h3 a:hover{color:var(--teal);}
.tr-meta{font-family:var(--mono);font-size:0.78rem;color:var(--ink-soft);}

@media (max-width:760px){ .co-grid{grid-template-columns:1fr;} }

/* media / animation frame */
.mediaframe{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--cream);padding:14px;}
.mediaframe img{width:100%;display:block;}
.media-links{display:flex;flex-wrap:wrap;gap:16px;margin-top:14px;font-family:var(--mono);font-size:0.85rem;}
.media-links a{font-weight:700;}

/* gene page */
.genefacts{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--paper);}
.factrow{display:grid;grid-template-columns:170px 1fr;gap:14px;padding:11px 18px;border-bottom:2px solid #ece6d9;font-size:0.95rem;}
.factrow:last-child{border-bottom:0;}
.factk{font-family:var(--mono);font-size:0.78rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--ink-soft);}
.factv{font-weight:500;}
.exprchart{display:flex;flex-direction:column;gap:7px;}
.exprrow{display:grid;grid-template-columns:170px 1fr 44px;gap:12px;align-items:center;}
.exprlabel{font-family:var(--mono);font-size:0.8rem;text-align:right;color:var(--ink);}
.exprtrack{background:var(--cream);border:2px solid var(--line);height:20px;position:relative;overflow:hidden;}
.exprfill{position:absolute;left:0;top:0;bottom:0;background:repeating-linear-gradient(45deg,var(--teal),var(--teal) 8px,#0b7d73 8px,#0b7d73 16px);}
.exprval{font-family:var(--mono);font-size:0.82rem;font-weight:700;color:var(--coral);}
.seqblock{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--ink);color:#c9f5ee;padding:16px 18px;overflow-x:auto;font-family:var(--mono);font-size:0.8rem;line-height:1.9;letter-spacing:1px;}
.seqline{white-space:pre;} .seqpos{color:var(--amber);user-select:none;}

/* body map */
.bodywrap{display:grid;grid-template-columns:300px 1fr;gap:30px;align-items:start;}
.bodymap{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--cream);padding:10px;}
.bodymap svg{width:100%;height:auto;display:block;}
.silhouette *{fill:#e8e3d6;stroke:#17171e;stroke-width:2;}
.hot circle:first-child{fill:rgba(14,148,136,0.16);stroke:var(--teal);stroke-width:2;cursor:pointer;transition:fill .12s;}
.hot .hotdot{fill:var(--teal);stroke:none;animation:pulse 1.8s ease-in-out infinite;}
.hot:hover circle:first-child,.hot.on circle:first-child{fill:rgba(240,96,58,0.28);stroke:var(--coral);}
.hot.on .hotdot{fill:var(--coral);}
@keyframes pulse{0%,100%{opacity:0.5;}50%{opacity:1;}}
@media (prefers-reduced-motion:reduce){.hot .hotdot{animation:none;}}
.dxpanel{position:sticky;top:90px;border:3px solid var(--line);box-shadow:var(--shadow);background:var(--paper);}
.dxpanel-inner{padding:20px 22px;}
.dxpanel-hint{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;letter-spacing:1px;color:var(--coral);}
.dxpanel h3{font-family:var(--disp);font-weight:700;font-size:1.3rem;margin:8px 0 6px;}
.dxlinks{display:flex;flex-wrap:wrap;gap:14px;margin-top:10px;font-family:var(--mono);font-size:0.82rem;font-weight:700;}
.dxlist{list-style:none;padding:0;margin:16px 0 0;display:grid;grid-template-columns:1fr 1fr;gap:16px;}
.dxcard{border:2px solid var(--line);padding:16px 18px;background:var(--paper);scroll-margin-top:90px;}
.dxcard:hover{box-shadow:var(--shadow-sm);}
.dxorgan{font-family:var(--mono);font-size:0.72rem;text-transform:uppercase;letter-spacing:0.5px;color:var(--teal);}
.dxcard h3{font-family:var(--disp);font-weight:700;font-size:1.15rem;margin:3px 0 8px;}
.dxcard p{font-size:0.92rem;margin:0 0 10px;}

/* explore filters */
.filters{border:3px solid var(--line);box-shadow:var(--shadow);background:var(--cream);padding:16px 18px;margin-bottom:26px;display:flex;flex-wrap:wrap;gap:16px 22px;align-items:center;}
.fgroup{display:flex;align-items:center;gap:8px;flex-wrap:wrap;}
.flabel{font-family:var(--mono);font-size:0.7rem;text-transform:uppercase;letter-spacing:1px;color:var(--ink-soft);}
.fbtn{font-family:var(--mono);font-size:0.8rem;border:2px solid var(--line);background:var(--paper);color:var(--ink);padding:4px 11px;cursor:pointer;border-radius:999px;}
.fbtn:hover{background:#efe9dc;}
.fbtn.on{background:var(--ink);color:var(--paper);}
.fbtn.clear{border-style:dashed;}
#ftag{font-family:var(--mono);font-size:0.8rem;border:2px solid var(--line);background:var(--paper);padding:4px 8px;}
.fcount{font-family:var(--mono);font-size:0.78rem;color:var(--coral);font-weight:700;}
.exp-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(320px,1fr));gap:18px;}
.exp-card{border:2px solid var(--line);padding:18px 20px;background:var(--paper);}
.exp-card:hover{box-shadow:var(--shadow-sm);}
.exp-meta{font-family:var(--mono);font-size:0.72rem;color:var(--ink-soft);display:flex;gap:12px;flex-wrap:wrap;margin-bottom:6px;align-items:center;}
.exp-domain{padding:1px 7px;border:2px solid var(--line);font-weight:700;text-transform:uppercase;letter-spacing:0.5px;}
.exp-domain.d1{background:#d6f5f0;} .exp-domain.d2{background:#f0ebff;}
.exp-card h3{font-family:var(--disp);font-weight:700;font-size:1.12rem;margin:0 0 8px;line-height:1.22;}
.exp-card h3 a{color:var(--ink);} .exp-card h3 a:hover{color:var(--teal);}
.exp-card p{font-size:0.9rem;margin:0 0 8px;}

@media (max-width:760px){
  .bodywrap{grid-template-columns:1fr;} .bodymap{max-width:300px;margin:0 auto;} .dxpanel{position:static;}
  .dxlist,.exp-grid{grid-template-columns:1fr;}
  .factrow{grid-template-columns:120px 1fr;} .exprrow{grid-template-columns:120px 1fr 38px;} .exprlabel{font-size:0.72rem;}
}
@media (max-width:560px){ body{font-size:16px;} article.full h1{font-size:1.8rem;} }

/* ===== mobile nav (hamburger) ===== */
@media (max-width:900px){
  .site-header .wrap{flex-wrap:wrap;}
  .nav-toggle{display:inline-flex;flex-direction:column;justify-content:center;gap:5px;width:42px;height:36px;padding:0 8px;border:2px solid var(--line);background:var(--paper);cursor:pointer;}
  .nav-toggle span{display:block;height:3px;width:100%;background:var(--ink);transition:transform .2s,opacity .2s;}
  .nav-toggle[aria-expanded="true"] span:nth-child(1){transform:translateY(8px) rotate(45deg);}
  .nav-toggle[aria-expanded="true"] span:nth-child(2){opacity:0;}
  .nav-toggle[aria-expanded="true"] span:nth-child(3){transform:translateY(-8px) rotate(-45deg);}
  nav.main{display:none;flex-basis:100%;width:100%;flex-direction:column;align-items:stretch;gap:0;order:3;padding-top:8px;}
  nav.main.open{display:flex;}
  nav.main a,.hasmenu>a{padding:12px 8px;border:0;border-bottom:1px solid #ece6d9;width:100%;font-size:0.98rem;white-space:normal;}
  nav.main a.nav-feature{border-bottom:1px solid var(--line);}
  .hasmenu{width:100%;position:static;}
  .hasmenu>a{justify-content:space-between;}
  .hasmenu::after{display:none;}
  .submenu{position:static;opacity:1;visibility:visible;transform:none;box-shadow:none;border:0;border-left:3px solid var(--teal);min-width:0;margin:0 0 6px 14px;padding:0;}
  .submenu a{padding:9px 10px;border-bottom:1px solid #f2eee4;white-space:normal;}
  .nav-search{width:100%;justify-content:center;margin:10px 0 4px;padding:10px;}
  .nav-search .kbd{display:none;}
}